Title ：A novel brainstem-targeted G51D alpha-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction.

Authors ：Shinnosuke Yasugaki,1 , Ami Kaneko,1 , Hibiki Okamura, Hideki Hayakawa, Kensuke Ikenaka, Cesar Aguirre, Masashi Yanagisawa, Hideki Mochizuki, Kousuke Baba, Yu Hayashi.

［Message from Ms, Ami Kaneko］
As a model of REM sleep behavior disorder (RBD), a prodromal symptom of Parkinson’s disease, we established a mouse model that reflects brainstem-initiated pathological progression by microinjecting familial Parkinson’s disease–associated G51D mutant α-synuclein fibrils into the pons, a key region for REM sleep regulation.
I sincerely thank all co-authors and everyone who supported this work.

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